Systems used to automatically annotate proteins with high accuracy:. Select item s and click on "Add to basket" to create your own collection here entries max. Manual assertion based on experiment in i.
Manual assertion inferred from combination of experimental and computational evidence i. Comprehensive resource for the study of protein post-translational modifications Peptidylglycine alpha-amidating enzyme peel in human, mouse and rat. The displayed sequence is further processed into a mature form. This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.
Show all Align All. This isoform has been chosen as the 'canonical' sequence. All positional Peptidylglycine alpha-amidating enzyme peel in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. The sequence Peptidylglycine alpha-amidating enzyme peel this isoform differs from the canonical sequence as follows: Manual assertion based on opinion in i. You are using a version of browser that may not display all the features of this website.
Please consider upgrading your browser. Your basket is currently empty. Reviewed - Annotation score: Select a section on the left to see content. The monooxygenase part produces an unstable peptidyl 2-hydroxyglycine intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Inhibited by EDTA, phenylglyoxal and diethyl pyrocarbonate. Peptidylglycine alpha-hydroxylating monooxygenase EC: Peptidyl-alpha-hydroxyglycine alpha-amidating lyase EC: Peptidylamidoglycolate lyase Short name: Other locations Membrane ; Single-pass type I membrane protein. Extracellular region or secreted Secreted Note: Secreted from secretory granules. Extracellular region or secreted extracellular exosome Source: UniProtKB Inferred from high throughput direct assay i extracellular region Source: Ensembl Plasma Membrane plasma membrane Source: Ensembl integral component of membrane Source: Ensembl perinuclear region of cytoplasm Source: Ensembl secretory granule membrane Source: Once cleaved, a propeptide generally has no independent biological function.
ExpressionAtlas i P baseline and differential Genevisible search portal to normalized and curated expression data from Genevestigator More In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family. Additionally, this section gives relevant information on each alternative protein isoform. Align Add to basket Added to basket Note: Additional isoforms seem to exist.